Cart
sales@molnova.com
Home - Products - Others - Other Targets - TC-A 2317 hydrochloride

TC-A 2317 hydrochloride

CAS No. 1245907-03-2

TC-A 2317 hydrochloride( —— )

Catalog No. M27721 CAS No. 1245907-03-2

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TC-A 2317 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.
  • Description
    TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.(In Vivo):In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight.
  • In Vitro
    TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM.
  • In Vivo
    TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight.TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats. Animal Model:HCT-116 Xenograft mice mode Dosage:P.o.; daily for 14 days Administration:30 mg/kg Result:Growth of tumor was inhibited by 59% after 14 days.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245907-03-2
  • Formula Weight
    392.93
  • Molecular Formula
    C19H29ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CC(CCCC(C)(C)O)Nc1nc(Nc2cc(C)[nH]n2)cc(C)c1[N+]#[C-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hou X, et al. Superficial Chiral Etching on Achiral Metal-Organic Framework for Enantioselective Sorption. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):32264-32269.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 3-Chloro-L-Tyrosine

    3-Chlorotyrosine a specific marker of myeloperoxidase-catalyzed oxidation is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular myeloperoxidase halogenates tyrosine residues in plasma proteins and generates 3-chlorotyrosine (CY).

  • Arnicolide C

    Arnicolide C exhibits significant antiallergy activity.

  • Levulinic acid

    Levulinic acid derived from the degradation of cellulose is a precursor for the synthesis of biofuels such as ethyl levulinate.

Sign In Join Free